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Los cultivos modificados genéticamente no son más alergénicos que sus contrapartidas no modificadas

En esta reseña, los autores detallan los diversos pasos en el desarrollo de un transgénico en los que se tiene en cuenta el potencial alergénico.
Además, realizan una reseña sistemática de los trabajos sobre el tema.

Los datos muestran que los cultivos modificados genéticamente no son más alergénicos que sus contrapartidas no modificadas. Tampoco se encontraron evidencias de alergenicidad en individuos que no son alérgicos al alimento convencional.

Evaluation of Reference Genes and Expression Level of Genes Potentially Involved in the Mode of Action of Cry1Ac and Cry1F in a Susceptible Reference Strain of Chrysodeixis includens

Elucidating SNP-based genetic diversity and population structure of advanced breeding lines of bread wheat ( Triticum aestivum L . )

Unraveling individual host-guest interactions in molecular recognition from first principles quantum mechanics: Insights into the nature of nicotinic acetylcholine receptor agonist binding

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Roeder, J., Liu, J., Doch, I., Ruschhaupt, M., Christmann, A., Grill, E., Helmke, H., Hohmann, S., Lehr, S., Frackenpohl, J., & Yang, Z. (2023). Abscisic acid agonists suitable for optimizing plant water use. Frontiers in Plant Science, 13, 1071710. https://doi.org/10.3389/fpls.2022.1071710
Ruedas, R., Couté, Y., Kieffer-Jacquinod, S., Sankari Muthukumar, S., Gillet, F.-X., Fenel, D., Effantin, G., Pfannschmidt, T., Blanvillain, R., & Cobessi, D. (2022). Three-dimensional envelope and subunit interactions of the plastid-encoded RNA polymerase from Sinapis alba [Preprint]. Biochemistry. https://doi.org/10.1101/2022.05.04.490580
Scanes, C. G., Witt, J., Ebeling, M., Schaller, S., Baier, V., Bone, A. J., Preuss, T. G., & Heckmann, D. (2022). Quantitative Morphometric, Physiological, and Metabolic Characteristics of Chickens and Mallards for Physiologically Based Kinetic Model Development. Frontiers in Physiology, 13, 858283. https://doi.org/10.3389/fphys.2022.858283
Scanes, C. G., Witt, J., Ebeling, M., Schaller, S., Baier, V., Bone, A. J., Preuss, T. G., & Heckmann, D. (2022). Quantitative Comparison of Avian and Mammalian Physiologies for Parameterization of Physiologically Based Kinetic Models. Frontiers in Physiology, 13, 858386. https://doi.org/10.3389/fphys.2022.858386
Kusch, S., Vaghefi, N., Takamatsu, S., Liu, S.-Y., Németh, M. Z., Seress, D., Frantzeskakis, L., Chiu, P.-E., Panstruga, R., & Kiss, L. (2022). First Draft Genome Assemblies of Pleochaeta shiraiana and Phyllactinia moricola , Two Tree-Parasitic Powdery Mildew Fungi with Hemiendophytic Mycelia. Phytopathology®, 112(4), 961–967. https://doi.org/10.1094/PHYTO-08-21-0337-A
Kusch, S., Frantzeskakis, L., Lassen, B. D., Kümmel, F., Pesch, L., Barsoum, M., Wu, H., Walden, K. D., & Panstruga, R. (2021). A fungal plant pathogen overcomes conserved broad-spectrum disease resistance by rapid gene loss [Preprint]. Plant Biology. https://doi.org/10.1101/2021.12.09.471931
Martin, M., Boaventura, D., & Nauen, R. (2021). Evaluation of Reference Genes and Expression Level of Genes Potentially Involved in the Mode of Action of Cry1Ac and Cry1F in a Susceptible Reference Strain of Chrysodeixis includens. Insects, 12(7), 598. https://doi.org/10.3390/insects12070598
Tomar, V., Dhillon, G. S., Singh, D., Singh, R. P., Poland, J., Joshi, A. K., Tiwari, B. S., & Kumar, U. (2021). Elucidating SNP-based genetic diversity and population structure of advanced breeding lines of bread wheat ( Triticum aestivum L . ). PeerJ, 9, e11593. https://doi.org/10.7717/peerj.11593
Beck, M. E., Riplinger, C., Neese, F., & Bistoni, G. (2021). Unraveling individual host-guest interactions in molecular recognition from first principles quantum mechanics: Insights into the nature of nicotinic acetylcholine receptor agonist binding. Journal of Computational Chemistry, 42(5), 293–302. https://doi.org/10.1002/jcc.26454
Lansbergen, B., Meister, C. S., & McLeod, M. C. (2021). Unexpected rearrangements and a novel synthesis of 1,1-dichloro-1-alkenones from 1,1,1-trifluoroalkanones with aluminium trichloride. Beilstein Journal of Organic Chemistry, 17, 404–409. https://doi.org/10.3762/bjoc.17.36
Sharma, D., Karre, A. V., & Valsaraj, K. T. (2021). Evaluations of the capacity of an existing brine system and estimation of salt loading profile for increased soft water demand to avoid soil contamination. The Canadian Journal of Chemical Engineering, cjce.23937. https://doi.org/10.1002/cjce.23937
Meskhidze, N., Sutherland, B., Ling, X., Dawson, K., Johnson, M. S., Henderson, B., Hostetler, C. A., & Ferrare, R. A. (2021). Improving estimates of PM2.5 concentration and chemical composition by application of High Spectral Resolution Lidar (HSRL) and Creating Aerosol Types from chemistry (CATCH) algorithm. Atmospheric Environment, 250, 118250. https://doi.org/10.1016/j.atmosenv.2021.118250
Marin Zapata, P. A., Roth, S., Schmutzler, D., Wolf, T., Manesso, E., & Clevert, D.-A. (2020). Self-supervised feature extraction from image time series in plant phenotyping using triplet networks. Bioinformatics (Oxford, England). https://doi.org/10.1093/bioinformatics/btaa905
Thomson, C. J., Barber, D. M., & Dixon, D. J. (2020). Catalytic Enantioselective Direct Aldol Addition of Aryl Ketones to α-Fluorinated Ketones. Angewandte Chemie (International Ed. in English), 59(13), 5359–5364. https://doi.org/10.1002/anie.201916129
Aumer, T., Voisin, S. N., Knobloch, T., Landon, C., & Bulet, P. (2020). Impact of an Antifungal Insect Defensin on the Proteome of the Phytopathogenic Fungus Botrytis cinerea. Journal of Proteome Research, 19(3), 1131–1146. https://doi.org/10.1021/acs.jproteome.9b00638
Bollinger, A., Molitor, R., Thies, S., Koch, R., Coscolín, C., Ferrer, M., & Jaeger, K.-E. (2020). Organic-Solvent-Tolerant Carboxylic Ester Hydrolases for Organic Synthesis. Applied and Environmental Microbiology, 86(9), e00106-20, /aem/86/9/AEM.00106-20.atom. https://doi.org/10.1128/AEM.00106-20
Frackenpohl, J., Decker, L. J. B., Dittgen, J., Freigang, J., Génix, P., Helmke, H., Lange, G., Luemmen, P., Schmidt, J., Schmutzler, D., & Vors, J.-P. (2020). Tetrahydroquinolinyl phosphinamidates and phosphonamidates enhancing tolerance towards drought stress in crops via interaction with ABA receptor proteins. Bioorganic & Medicinal Chemistry, 28(22), 115725. https://doi.org/10.1016/j.bmc.2020.115725
Daoud, F., Zuehlke, S., Spiteller, M., & Kayser, O. (2020). Corrigendum to “Ozonation of rivaroxaban production waste water and comparison of generated transformation products with known in vivo and in vitro metabolites” [Sci. Total Environ. 714 (2020), 136825]. Science of The Total Environment, 742, 140865. https://doi.org/10.1016/j.scitotenv.2020.140865
Kim, J. H., Lagojda, A., Kuehne, D., Tshitenge, D. T., Chaudhuri, S., Walker, D. P., & Head, G. (2020). Determination of Cotton as a Larval Feeding Source for Lepidopteran Moths Using a Derivative from Cotton Metabolites as a Marker by LC-MS/MS Method. Journal of Chemical Ecology, 46(10), 956–966. https://doi.org/10.1007/s10886-020-01219-w
Daws, S. C., Cline, L. A., Rotenberry, J., Sadowsky, M. J., Staley, C., Dalzell, B., & Kennedy, P. G. (2020). Do shared traits create the same fates? Examining the link between morphological type and the biogeography of fungal and bacterial communities. Fungal Ecology, 46, 100948. https://doi.org/10.1016/j.funeco.2020.100948
Joshua, J., & Mmbaga, M. T. (2020). Potential Biological Control Agents for Soilborne Fungal Pathogens in Tennessee Snap Bean Farms. HortScience, 55(7), 988–994. https://doi.org/10.21273/HORTSCI14081-19
Daoud, F., Zuehlke, S., Spiteller, M., & Kayser, O. (2020). Ozonation of rivaroxaban production waste water and comparison of generated transformation products with known in vivo and in vitro metabolites. Science of The Total Environment, 714, 136825. https://doi.org/10.1016/j.scitotenv.2020.136825
Araújo, K. S., Brito, V. N., Veloso, T. G. R., de Leite, T. S., Alves, J. L., da Hora Junior, B. T., Moreno, H. L. A., Pereira, O. L., Mizubuti, E. S. G., & de Queiroz, M. V. (2020). Diversity and distribution of endophytic fungi in different tissues of Hevea brasiliensis native to the Brazilian Amazon forest. Mycological Progress, 19(10), 1057–1068. Scopus. https://doi.org/10/gk9ttq
Kalske, A., Shiojiri, K., Uesugi, A., Sakata, Y., Morrell, K., & Kessler, A. (2019). Insect Herbivory Selects for Volatile-Mediated Plant-Plant Communication. Current Biology: CB, 29(18), 3128-3133.e3. https://doi.org/10.1016/j.cub.2019.08.011
Piližota, I., Train, C.-M., Altenhoff, A., Redestig, H., & Dessimoz, C. (2019). Phylogenetic approaches to identifying fragments of the same gene, with application to the wheat genome. Bioinformatics (Oxford, England), 35(7), 1159–1166. https://doi.org/10.1093/bioinformatics/bty772
Argueso, C. T., Assmann, S. M., Birnbaum, K. D., Chen, S., Dinneny, J. R., Doherty, C. J., Eveland, A. L., Friesner, J., Greenlee, V. R., Law, J. A., Marshall-Colón, A., Mason, G. A., O’Lexy, R., Peck, S. C., Schmitz, R. J., Song, L., Stern, D., Varagona, M. J., Walley, J. W., & Williams, C. M. (2019). Directions for research and training in plant omics: Big Questions and Big Data. Plant Direct, 3(4), e00133. https://doi.org/10.1002/pld3.133
Thomson, C. J., Barber, D. M., & Dixon, D. J. (2019). One-Pot Catalytic Enantioselective Synthesis of 2-Pyrazolines. Angewandte Chemie (International Ed. in English), 58(8), 2469–2473. https://doi.org/10.1002/anie.201811471
Daghino, S., Di Vietro, L., Petiti, L., Martino, E., Dallabona, C., Lodi, T., & Perotto, S. (2019). Yeast expression of mammalian Onzin and fungal FCR1 suggests ancestral functions of PLAC8 proteins in mitochondrial metabolism and DNA repair. Scientific Reports, 9(1), 6629. https://doi.org/10.1038/s41598-019-43136-3
Kia, S. H., Pallesch, S., Piepenbring, M., & Maciá-Vicente, J. G. (2019). Root endophytic fungi show low levels of interspecific competition in planta. Fungal Ecology, 39, 184–191. https://doi.org/10.1016/j.funeco.2019.02.009
Mebane, C. A., Sumpter, J. P., Fairbrother, A., Augspurger, T. P., Canfield, T. J., Goodfellow, W. L., Guiney, P. D., LeHuray, A., Maltby, L., Mayfield, D. B., McLaughlin, M. J., Ortego, L. S., Schlekat, T., Scroggins, R. P., & Verslycke, T. A. (2019). Scientific integrity issues in Environmental Toxicology and Chemistry: Improving research reproducibility, credibility, and transparency. Integrated Environmental Assessment and Management, 15(3), 320–344. https://doi.org/10.1002/ieam.4119
Wilkinson, M. D., Dumontier, M., Jan Aalbersberg, I., Appleton, G., Axton, M., Baak, A., Blomberg, N., Boiten, J.-W., da Silva Santos, L. B., Bourne, P. E., Bouwman, J., Brookes, A. J., Clark, T., Crosas, M., Dillo, I., Dumon, O., Edmunds, S., Evelo, C. T., Finkers, R., … Mons, B. (2019). Erratum: Addendum: The FAIR Guiding Principles for scientific data management and stewardship (Scientific data (2016) 3 (160018)). Scientific Data, 6(1), 6. Scopus. https://doi.org/10/gf3j9x
Vincent, D., Rafiqi, M., & Job, D. (2019). The Multiple Facets of Plant-Fungal Interactions Revealed Through Plant and Fungal Secretomics. Frontiers in Plant Science, 10, 1626. https://doi.org/10.3389/fpls.2019.01626
Eckelmann, D., Kusari, S., & Spiteller, M. (2018). Stable Isotope Labeling of Prodiginines and Serratamolides Produced by Serratia marcescens Directly on Agar and Simultaneous Visualization by Matrix-Assisted Laser Desorption/Ionization Imaging High-Resolution Mass Spectrometry. Analytical Chemistry, 90(22), 13167–13172. https://doi.org/10.1021/acs.analchem.8b03633
Tesch, R., Becker, C., Müller, M. P., Beck, M. E., Quambusch, L., Getlik, M., Lategahn, J., Uhlenbrock, N., Costa, F. N., Polêto, M. D., Pinheiro, P. de S. M., Rodrigues, D. A., Sant’Anna, C. M. R., Ferreira, F. F., Verli, H., Fraga, C. A. M., & Rauh, D. (2018). An Unusual Intramolecular Halogen Bond Guides Conformational Selection. Angewandte Chemie (International Ed. in English), 57(31), 9970–9975. https://doi.org/10.1002/anie.201804917
Robin, G. P., Kleemann, J., Neumann, U., Cabre, L., Dallery, J.-F., Lapalu, N., & O’Connell, R. J. (2018). Subcellular Localization Screening of Colletotrichum higginsianum Effector Candidates Identifies Fungal Proteins Targeted to Plant Peroxisomes, Golgi Bodies, and Microtubules. Frontiers in Plant Science, 9, 562. https://doi.org/10.3389/fpls.2018.00562
Nowak, K. M., Telscher, M., Seidel, E., & Miltner, A. (2018). Unraveling microbial turnover and non-extractable residues of bromoxynil in soil microcosms with 13C-isotope probing. Environmental Pollution, 242, 769–777. https://doi.org/10.1016/j.envpol.2018.07.049
Varela, S., Assefa, Y., Vara Prasad, P. V., Peralta, N. R., Griffin, T. W., Sharda, A., Ferguson, A., & Ciampitti, I. A. (2017). Spatio-temporal evaluation of plant height in corn via unmanned aerial systems. Journal of Applied Remote Sensing, 11(03), 1. https://doi.org/10.1117/1.JRS.11.036013
Lee, M.-S., Anderson, E. K., Stojšin, D., McPherson, M. A., Baltazar, B., Horak, M. J., de la Fuente, J. M., Wu, K., Crowley, J. H., Rayburn, A. L., & Lee, D. K. (2017). Assessment of the potential for gene flow from transgenic maize (Zea mays L.) to eastern gamagrass (Tripsacum dactyloides L.). Transgenic Research, 26(4), 501–514. https://doi.org/10.1007/s11248-017-0020-7
Cabrera, A. R., Shirk, P. D., & Teal, P. E. A. (2017). A feeding protocol for delivery of agents to assess development in Varroa mites. PLOS ONE, 12(4), e0176097. https://doi.org/10.1371/journal.pone.0176097
Abts, W., Vandenbussche, B., De Proft, M. P., & Van de Poel, B. (2017). The Role of Auxin-Ethylene Crosstalk in Orchestrating Primary Root Elongation in Sugar Beet. Frontiers in Plant Science, 8. https://doi.org/10.3389/fpls.2017.00444
Soares, D. J., Oliveira, W., Uzuele, E., Carvalho, S., Ovejero, R., & Christoffoleti, P. (2017). Growth and development of Conyza bonariensis based on days or thermal units. Pesquisa Agropecuária Brasileira, 52, 45–53. https://doi.org/10.1590/s0100-204x2017000100006
Matthiessen, P., Ankley, G. T., Biever, R. C., Bjerregaard, P., Borgert, C., Brugger, K., Blankinship, A., Chambers, J., Coady, K. K., Constantine, L., Dang, Z., Denslow, N. D., Dreier, D. A., Dungey, S., Gray, L. E., Gross, M., Guiney, P. D., Hecker, M., Holbech, H., … Yamazaki, K. (2017). Recommended approaches to the scientific evaluation of ecotoxicological hazards and risks of endocrine-active substances: Ecotoxicological Evaluation of Endocrine-Active Substances. Integrated Environmental Assessment and Management, 13(2), 267–279. https://doi.org/10.1002/ieam.1885
Heredia Díaz, O., Aldaba Meza, J. L., Baltazar, B. M., Bojórquez Bojórquez, G., Castro Espinoza, L., Corrales Madrid, J. L., de la Fuente Martínez, J. M., Durán Pompa, H. A., Alonso Escobedo, J., Espinoza Banda, A., Garzón Tiznado, J. A., González García, J., Guzmán Rodríguez, J. L., Madueño Martínez, J. I., Martínez Carrillo, J. L., Meng, C., Quiñones Pando, F. J., Rosales Robles, E., Ruiz Hernández, I., … Zavala García, F. (2017). Plant characterization of genetically modified maize hybrids MON-89Ø34-3 × MON-88Ø17-3, MON-89Ø34-3 × MON-ØØ6Ø3-6, and MON-ØØ6Ø3-6: alternatives for maize production in Mexico. Transgenic Research, 26(1), 135–151. https://doi.org/10.1007/s11248-016-9991-z
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Francischini, J. H. M. B., Kemper, E. L., Costa, J. B., Manechini, J. R. V., & Pinto, L. R. (2017). DNA methylation in sugarcane somaclonal variants assessed through methylation-sensitive amplified polymorphism. Genetics and Molecular Research, 16(2), 16029585. https://doi.org/10.4238/gmr16029585
Settlage, S. B., Eble, J. E., Bhanushali, J. K., Cheever, M. L., Gao, A. G., Goldstrohm, D. A., Hill, R., Hu, T. X., Powley, C. R., Unger, A., & Shan, G. M. (2017). Validation Parameters for Quantitating Specific Proteins Using ELISA or LC-MS/MS: Survey Results. Food Analytical Methods, 10(5), 1339–1348. https://doi.org/10.1007/s12161-016-0689-x
Ssegane, H., Amatya, D. M., Muwamba, A., Chescheir, G. M., Appelboom, T., Tollner, E. W., Nettles, J. E., Youssef, M. A., Birgand, F., & Skaggs, R. W. (2017). Calibration of paired watersheds: Utility of moving sums in presence of externalities. Hydrological Processes, 31(20), 3458–3471. https://doi.org/10.1002/hyp.11248
Tan, Y. S., Miao, Z. W., Abdul, M. M., Grift, T. E., & Ting, K. C. (2017). Electrical capacitance as a proxy measurement of miscanthus bulk density, and the influence of moisture content and particle size. Computers and Electronics in Agriculture, 134, 102–108. https://doi.org/10.1016/j.compag.2017.01.013
Wang, B. H., Zhuang, Z. M., Zhang, Z. S., Draye, X., Shuang, L. S., Shehzad, T., Lubbers, E. L., Jones, D., May, O. L., Paterson, A. H., & Chee, P. W. (2017). Advanced Backcross QTL Analysis of Fiber Strength and Fineness in a Cross between Gossypium hirsutum and G. Mustelinum. Frontiers in Plant Science, 8(10).
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As referências citadas são obtidas por meio de serviços de pesquisa bibliográfica, com base na afiliação do autor à Bayer. Isso pode levar esporadicamente a casos em que as postagens de autores que ingressaram na Bayer recentemente são referenciadas, mesmo que o trabalho de pesquisa tenha sido realizado na instituição ou organização anterior do autor.

Algumas publicações endossadas ou patrocinadas pela Bayer, mas desenvolvidas / escritas de forma independente e / ou não incluem um autor da Bayer, podem não ser mencionadas.

Por motivos de direitos autorais, o acesso ao texto completo das publicações depende dos direitos de acesso do indivíduo ou do periódico.


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